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The importance of ISAV HPR0 for causing clinical outbreak of ISA

Project number: FHF/901051

Characterization of ISA virus HPR
The Veterinary Institute currently has several different primary cells from Atlantic salmon in long term cultures. In the project, these will be tested to establish a method / procedure for in vivo cultivation of HPR0. Amplified virus will be used in transmission experiments. A "first generation" HPR-deleted ISA virus has in infection experiments proved to give low mortality. Further characterization of this virus variant, will support the establishment of a model system for challenge with HPR0 and is by itself a good system for investigating possible mutations.

Through challenge experiments we will generate material for investigating/ describe mechanisms and genetic markers associated to various stages in the transition from HPR0 / low-virulent HPR-deleted ISA virus to virulent HPR-deleted ISA virus that will increase our understanding of HPR0 virus, HPR0 infection (interaction host-agent) and criteria for a possible mutation. 

Identification of sites with increased risk of ISA
The project will develop a method for ranking of individual site risk of ISA (based on the presence of HPR0 and local spread of virulent HPR-deleted ISA virus) by determining a quantitative risk estimate for each site. Such a model will be useful both in terms of more effective and risk-based surveillance, and the possibility to implement more optimal disease prevention. Ranking of sites will be based on factors such as fallowing management, biomass density, mortality, sea temperature, distance to the slaughterhouse, others diseases, lice treatment etc. The analysis will be based on isolated ISA outbreak of 2003-2014, aquaculture data and journal data from the Norwegian Veterinary Institute and knowledge generated in subproject 1. 

Seminar / workshop - ISAV HPR0
ISA and especially ISA virus HPR0, has received considerable attention resulting in OIE making HPR0 notifiable. Currently, there is research related to HPR0 in Chile, Canada, the Faroe Islands and Scotland as well as Norway. The project would therefore like to arrange a workshop (workshop) relating to research on HPR0, where also other relevant stakeholders as industry, the FSA, fish health, etc. are invited.


Project leader
Edgar Brun

Reference group consisting of:
Niels Jørgen Olesen, DTU, EU fish reference laboratory, Denmark 
Sergio H. Marshall, Universitetet i Valparaiso, Chile
Debes Christinansen, Food and Veterinary Agency, Faroe Islands 
Edmund Peeler, CEFAS, UK
Birgit C. Oidtman, CEFAS, UK

Duration: 01.01.2015 - 31.12.2017


Brun Edgar


Falk Knut


Sindre Hilde


Hauge Helena


Aamelfot Maria

Forsker / Researcher