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Effects on bone tissue in ewes (Ovies aries) and their foetuses exposed to PCB 118 and PCB 153

Gutleb AC, Arvidsson D, Orberg J, Larsson S, Skaare JU, Aleksandersen M, Ropstad E, Lind PM. Effects on bone tissue in ewes (Ovies aries) and their foetuses exposed to PCB 118 and PCB 153. TOXICOLOGY LETTERS 2010; 192 (2): 126-33

The aim of the present study was to investigate whether low levels of mono-ortho PCB 118 and di-ortho PCB 153, affect bone composition and strength in ewes (Dala breed) and their foetuses following exposure starting at conception and ending a week before expected delivery. In male foetuses, trabecular bone mineral content at the metaphysis was almost 30% lower in the PCB 118 (49 mu g/kg body wt/day) group compared to the control group (corn oil) (ANCOVA, P<0.05). In female foetuses of the PCB 153 (98 mu g/kg body wt/day) group trabecular cross-sectional area at the metaphysis was 19% smaller than in the controls (ANCOVA, P<0.05). At the diaphysis a smaller marrow cavity area (up to 24% reduction) was observed in female and male foetuses exposed to PCB 153 compared with controls (ANCOVA, P<0.05). There were also significant differences at the mid diaphyseal measure point between the PCB 153 and the control group females (ANCOVA, P<0.05). Cortical and total bone mineral density, cortical thickness were significantly higher, endosteal circumference shorter and marrow cavity significantly smaller in the PCB 153 group (ANCOVA, P<0.05).

In conclusion there were gender dependent effects on bone tissue and cortical bone was more affected than trabecular bone. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

NVI authors

Skåre Janneche Utne

Head of Research Department